Welcome to the Saier Lab
Our laboratory takes a multidisciplinary approach to science, using biochemical, molecular genetic, physiological, and bioinformatic approaches. We have three primary research interests, one concerned with transcriptional and metabolic regulation in bacteria, a second with transport protein evolution, and a third with the recently identified process of transposon-mediated directed mutation. We also created and now maintain the Transporter Classification DataBase (TCDB), which was adopted by the International Union of Biochemistry and Molecular Biology (IUBMB) as the primary source of information relating to molecular transport.
About us
Dr. Milton Saier is the head of the laboratory. The lab has two main branches: the wet lab (led by Dr. Zhongge Zhang) and the dry lab (led by Dr. Arturo Medrano-Soto). The progress of our experimental and bioinformatic projects depends on the work and interaction within our wonderfully eclectic Team of researchers, talented students, visiting scholars and external collaborators. For more details, please visit our Research and Publications pages. The software developed and maintained by our bioinformatics team is available in our GitHub repository and our web applications are available in our BioTools page, Please, do not hesitate to contact us If you have any questions/requests or if you would like to give us feedback.
Latest News
MSc degree obtained
Congratulations to our grad student Nuo Tian for a successful defense of her Master's thesis on Jan 12, 2021. The title of her thesis is "Structural and evolutionary relationships within the ATP-binding cassette (ABC) superfamily". Abstract ATP-binding Cassette (ABC)...
Hot off the press
The Saier Lab just published the latest update and improvements to TCDB in the journal Nucleic Acids Research. The title is: "The Transporter Classification Database (TCDB): 2021 update". For your convenience, these are the links to PubMed and PMC. Abstract The...
Hot off the press
Our collaborator Dr. Zafar and Dr. Saier just published a paper in the journal Genes reporting a comparative genomics analysis of the transportomes of multiple Lactobacillus strains. The title is: "Comparative Genomics of the Transport Proteins of Ten Lactobacillus...