Welcome to the Saier Lab
Our laboratory takes a multidisciplinary approach to science, using biochemical, molecular genetic, physiological, and bioinformatic approaches. We have three primary research interests, one concerned with transcriptional and metabolic regulation in bacteria, a second with transport protein evolution, and a third with the recently identified process of transposon-mediated directed mutation. We also created and now maintain the Transporter Classification DataBase (TCDB), which was adopted by the International Union of Biochemistry and Molecular Biology (IUBMB) as the primary source of information relating to molecular transport.
Dr. Milton Saier is the head of the laboratory. The lab has two main branches: the wet lab (led by Dr. Zhongge Zhang) and the dry lab (led by Dr. Arturo Medrano-Soto). The progress of our experimental and bioinformatic projects depends on the work and interaction within our wonderfully eclectic Team of researchers, talented students, visiting scholars and external collaborators. For more details, please visit our Research and Publications pages. The software developed and maintained by our bioinformatics team is available in our GitHub repository and our web applications are available in our BioTools page, Please, do not hesitate to contact us If you have any questions/requests or if you would like to give us feedback.
MSc. K. J. K. Lam, Dr. Z. Zhang, and Dr. M. Saier just published a paper in the Computational and Structural Biotechnology Journal. The title is: Histone-like nucleoid structuring (H-NS) protein silences the beta-glucoside (bgl) utilization operon in Escherichia coli...
Congratulations to our grad student Peter Kopkowski for a successful defense of his Master's thesis on October 26, 2022. The title of his thesis is "The Effects of DNA-Binding Proteins on IS Element Insertion Upstream of the bgl Operon in Escherichia coli".
MSc. D. Tran, Dr. Z. Zhang, MSc. K.J.K. Lam and Dr. M. Saier just published a paper in the International Journal of Molecular Sciences. The title is: Effects of Global and Specific DNA-Binding Proteins on Transcriptional Regulation of the E. coli bgl Operon. For your...