Welcome to the Saier Lab

Our laboratory takes a multidisciplinary approach to science, using biochemical, molecular genetic, physiological, and bioinformatic approaches. We have three primary research interests, one concerned with transcriptional and metabolic regulation in bacteria, a second with transport protein evolution, and a third with the recently identified process of transposon-mediated directed mutation. We also created and now maintain the Transporter Classification DataBase (TCDB), which was adopted by the International Union of Biochemistry and Molecular Biology (IUBMB) as the primary source of information relating to molecular transport.

 

Our Research

About us

Dr. Milton Saier is the head of the laboratory. The lab has two main branches: the wet lab (led by Dr. Zhongge Zhang) and the dry lab (led by Dr. Arturo Medrano-Soto). The progress of our experimental and bioinformatic projects depends on the work and interaction within our wonderfully eclectic Team of researchers, talented students, visiting scholars and external collaborators. For more details, please visit our Research and Publications pages. The software developed and maintained by our bioinformatics team is available in our GitHub repository and our web applications are available in our BioTools page, Please, do not hesitate to contact us If you have any questions/requests or if you would like to give us  feedback.

Latest News

MSc degree obtained

MSc degree obtained

Congratulations to our grad student Katie Jing Kay Lam for a successful defense of her Master's thesis on April 15, 2022.  The title of her thesis is "Histone-like Nucleoid Structuring (H-NS) Protein Silences the β-Glucoside (bgl) Utilization Operon by Formation of a...

Hot off the press

Hot off the press

MSc Daniel Tyler, grad student Kevin Hendargo, Dr. Medrano-Soto and Dr. Saier just published a paper in the journal Microbial Physiology. The title is: Discovery and Characterization of the Phospholemman/SIMP/Viroporin Superfamily. For your convenience, this is the...

Hot off the press

Hot off the press

Dr.  Zhang, MSc Kingswell Zhou, MSc Dennis Tran and Dr. Saier just published a paper in the journal International Journal of Molecular Sciences. The title is: Insertion Sequence (IS) Element-Mediated Activating Mutations of the Cryptic Aromatic β-Glucoside Utilization...