Welcome to the Saier Lab
Our laboratory takes a multidisciplinary approach to science, using biochemical, molecular genetic, physiological, and bioinformatic approaches. We have three primary research interests, one concerned with transcriptional and metabolic regulation in bacteria, a second with transport protein evolution, and a third with the recently identified process of transposon-mediated directed mutation. We also created and now maintain the Transporter Classification DataBase (TCDB), which was adopted by the International Union of Biochemistry and Molecular Biology (IUBMB) as the primary source of information relating to molecular transport.
About us
Dr. Milton Saier is the head of the laboratory. The lab has two main branches: the wet lab (led by Dr. Zhongge Zhang) and the dry lab (led by Dr. Arturo Medrano-Soto). The progress of our experimental and bioinformatic projects depends on the work and interaction within our wonderfully eclectic Team of researchers, talented students, visiting scholars and external collaborators. For more details, please visit our Research and Publications pages. The software developed and maintained by our bioinformatics team is available in our GitHub repository and our web applications are available in our BioTools page, Please, do not hesitate to contact us If you have any questions/requests or if you would like to give us feedback.
Latest News
Hot off the press
Dr. M.. Saier and Dr. Z. Zhang in collaboration with Dr. I. Rodionova and several laboratories just published a paper in the jounral Scientific Reports. The title is: E. coli allantoinase is activated by the downstream metabolic enzyme, glycerate kinase, and...
MSc degree obtained
Congratulations to our grad student Harry Zhou for a successful defense of his master's thesis on April 20, 2023. The title of his thesis is "Characterization of the fucAO promoter and elucidating the transcriptional mechanism behind IS5-driven activation of the...
MSc degree obtained
Congratulations to our grad student Kevin J. Hendargo for a successful defense of his master's thesis on April 12, 2023. The title of his thesis is "Detection of Sequence Similarity Among Structural Repeats in the Piezo Family of Mechanosensitive Ion Channels"....