Welcome to the Saier Lab

Our laboratory takes a multidisciplinary approach to science, using biochemical, molecular genetic, physiological, and bioinformatic approaches. We have three primary research interests, one concerned with transcriptional and metabolic regulation in bacteria, a second with transport protein evolution, and a third with the recently identified process of transposon-mediated directed mutation. We also created and now maintain the Transporter Classification DataBase (TCDB), which was adopted by the International Union of Biochemistry and Molecular Biology (IUBMB) as the primary source of information relating to molecular transport.

 

Our Research

About us

Dr. Milton Saier is the head of the laboratory. The lab has two main branches: the wet lab (led by Dr. Zhongge Zhang) and the dry lab (led by Dr. Arturo Medrano-Soto). The progress of our experimental and bioinformatic projects depends on the work and interaction within our wonderfully eclectic Team of researchers, talented students, visiting scholars and external collaborators. For more details, please visit our Research and Publications pages. The software developed and maintained by our bioinformatics team is available in our GitHub repository and our web applications are available in our BioTools page, Please, do not hesitate to contact us If you have any questions/requests or if you would like to give us  feedback.

Latest News

Hot off the press

Hot off the press

Dr. Zafar and Dr. Saier just published a paper in the journal Microbial Physiology. The title is: Comparative Analyses of the Transport Proteins Encoded within the Genomes of nine Bifidobacterium Species. For your convenience, this is the link to PubMed.   Abstract...

Hot off the press

Hot off the press

Dr. Saier and collaborators  Irina A. Rodionova, Ye Gao, Anand Sastry, Ying Hefner, Hyun Gyu Lim, Dmitry A. Rodionov, and Bernhard O. Palsson just published a paper in the journal Communications Biology. The title is: "Identification of a transcription factor, PunR,...

MSc degree obtained

MSc degree obtained

Congratulations to our grad student Denis Tran for a successful defense of his Master's thesis on Jun 23, 2021.  The title of his thesis is "The effects of global and specific DNA-binding proteins on transcriptional regulation of the bgl operon". Abstract The bgl...