Welcome to the Saier Lab
Our laboratory takes a multidisciplinary approach to science, using biochemical, molecular genetic, physiological, and bioinformatic approaches. We have three primary research interests, one concerned with transcriptional and metabolic regulation in bacteria, a second with transport protein evolution, and a third with the recently identified process of transposon-mediated directed mutation. We also created and now maintain the Transporter Classification DataBase (TCDB), which was adopted by the International Union of Biochemistry and Molecular Biology (IUBMB) as the primary source of information relating to molecular transport.
About us
Dr. Milton Saier is the head of the laboratory. The lab has two main branches: the wet lab (led by Dr. Zhongge Zhang) and the dry lab (led by Dr. Arturo Medrano-Soto). The progress of our experimental and bioinformatic projects depends on the work and interaction within our wonderfully eclectic Team of researchers, talented students, visiting scholars and external collaborators. For more details, please visit our Research and Publications pages. The software developed and maintained by our bioinformatics team is available in our GitHub repository and our web applications are available in our BioTools page, Please, do not hesitate to contact us If you have any questions/requests or if you would like to give us feedback.
Latest News
Hot off the press
Drs. Arturo Medrano, Milton Saier and twelve other collaborators just published the paper "Key role of Desulfobacteraceae in C/S cycles of marine sediments is based on congeneric catabolic-regulatory networks" in the journal Science Advancesl. For your convenience,...
Hot off the press
Drs. Irina Rodionova, Gabriel Moreno-Hagelsieb, Milton Saier and many more collaborators just published the paper "Ligand interaction landscape of transcription factors and essential enzymes in E. coli" in the journal Cell. For your convenience, this is the link to...
Hot off the press
Dr. Milton Saier just published the paper "Cooperation and competition were primary driving forces for biological evolution" in the journal Microbial Physiology. For your convenience, this is the link to PubMed. Abstract: Background: For many years, scientists...